Abstract Search

ea0081p532 | Adrenal and Cardiovascular Endocrinology | ECE2022

Covid-19 in patients with hypocortisolism: clinical syndrome, disease duration and glucocorticoid replacement therapy

Simeoli Chiara , Schettino Serafina , La Rocca Angelica , Di Paola Nicola , Massimo Crescenzo Erminio , Ciardella Francesco , Mazzarella Alessandro , Pivonello Claudia , Colao Annamaria , Pivonello Rosario

Coronavirus disease caused by SARS-CoV-2 virus (Covid-19) is associated with a variable clinical syndrome, ranging from a mild-moderate to a severe disease, progressing towards acute respiratory distress syndrome. Hypocortisolism is associated with a depletion of innate immunity and disruption of immune response, which could contribute to an increased risk of infection and development of a severe disease. Glucocorticoid (GC) replacement therapy(GCRT), especially if administere...

0 shares

ea0090p691 | Pituitary and Neuroendocrinology | ECE2023

Diabetes Mellitus Secondary to Cushing’S Disease or Acromegaly: a Single-Centre Experience

Scairati Roberta , Di Meglio Sara , Pirchio Rosa , Vergura Alice , Di Paola Nicola , Larocca Angelica , Del Vecchio Guendalina , Simeoli Chiara , Simona Auriemma Renata , Colao Annamaria , Pivonello Rosario

Rationale: Type 2 diabetes mellitus (DM) is common in patients with Cushings disease (CD) and Acromegaly (AC), and contributes to increased mortality. This study aimed at investigating the prevalence and characteristics of DM in CD and AC patients at diagnosis and after disease control (DC).Patients and Methods: 34 CD patients (8M,26F, 24 microadenomas(mA),6 macroadenomas (MMA) and 4 empty sella) and 35 AC patients (16M,19F, 7 mA,28 MMA) were inclu...

2 shares

ea0081p430 | Pituitary and Neuroendocrinology | ECE2022

Psychological impact of Covid-19 national lockdown on patients with Cushing’s syndrome in Italy: a case-control study

Di Paola Nicola , Barbot Mattia , Ferrante Emanuele , Ferrau Francesco , Gatto Federico , Maria Paragliola Rosa , Reimondo Giuseppe , Arnaldi Giorgio , Guarnotta Valentina , Ferrigno Rosario , Simeoli Chiara , Mantovani Giovanna , Scaroni Carla , Iasevoli Felice , Colao Annamaria , Pivonello Rosario

During the spring of 2020, a national lockdown was adopted in Italy to prevent COVID-19 pandemic spread. Restrictive measures have been associated with impaired psychological outcome in the general population. As patients with Cushings Syndrome (CS), including Cushings disease (CD), adrenal CS (ACS), and ectopic CS (ECS), are reportedly associated with a higher prevalence of anxiety, stress susceptibility, depression, and maniac episodes, during both active disease...

0 shares

ea0090p410 | Pituitary and Neuroendocrinology | ECE2023

Impact of Surgery or Medical Treatment with the Selective Glucocorticoid Receptor Modulator Relacorilant on Hypercoagulopathy in Patients with Cushing Syndrome

Simeoli Chiara , Di Paola Nicola , Stigliano Antonio , Lardo Pina , Kearney Tara , Mezosi Emese , Ghigo Ezio , Giordano Roberta , Mariash Cary N. , Donegan Diane , Feelders Richard , Hand Austin , Moraitis Andreas G. , Pivonello Rosario

In patients with Cushing syndrome (CS), hypercoagulability represents a significant concern, leading to elevated risk for thrombotic events. After curative surgery, hypercoagulability persists for several months; CS treatment guidelines recommend anticoagulation therapy for ≤ 3 months. In patients with Cushing disease, hemostatic parameters may even worsen after surgery, independent of surgical outcome; improvements begin ~3 months after successful surgery (Casonato ...

1 shares

ea0090p811 | Late-Breaking | ECE2023

Comparison of Metyrapone, OSilodrostat and KEToconazolE in the short-term thERapy of endogenous Cushing’s syndrome: preliminary results of the MOSKETEER study

Detomas Mario , Simeoli Chiara , Ceccato Filippo , Aulinas Maso Ana , Dolce Pasquale , Rubinstein German , Antonini Simone , Stelmachowska-Banaś Maria , Minnetti Marianna , Corsello Andrea , Dischinger Ulrich , Di Paola Nicola , Voltan Giacomo , Santos Vives Alicia , Braun Leah , Mazzarella Alessandro , DEUTSCHBEIN Timo , Lania Andrea , Isidori Andrea , Reincke Martin , Carla Scaroni , M Webb Susan , Pivonello Rosario , Fassnacht Martin , Altieri Barbara

Background: Steroid synthesis inhibitors, like metyrapone, osilodrostat, and ketoconazole are used as second-line treatment in all types of endogenous Cushings syndrome (CS). However, a direct comparison of these three drugs is missing. This study aimed to compare these drugs in the short-term therapy of CS.Design: Retrospective multicenter study involving 15 European centers.Methods: Patients with CS treated with metyrapone,...

5 shares

ea0093oc14 | Oral communication 2: Neuroendocrinology | EYES2023

Comparison of metyrapone, osilodrostat and ketoconazole in the short-term therapy of endogenous Cushing’s syndrome: Preliminary results of the Mosketeer study

Detomas Mario , Simeoli Chiara , Di Paola Nicola , Mazzarella Alessandro , Pivonello Rosario , Ceccato Filippo , Voltan Giacomo , Scaroni Carla , Aulinas Anna , Santos Alicia , Webb Susan , Rubinstein German , Braun Leah , Reincke Martin , Dolce Pasquale , Antonini Simone , Lania Andrea , Stelmachowska-Banaś Maria , Cylke-Falkowska Karolina , Minnetti Marianna , Isidori Andrea M. , Corsello Andrea , Gilis-Januszewska Aleksandra , Minasyjan Mari , Sambula Lana , Kastelan Darko , Deutschbein Timo , Haberbosch Linus , Dischinger Ulrich , Fassnacht Martin , Altieri Barbara

Background: Steroid synthesis inhibitors, like metyrapone, osilodrostat, and ketoconazole are used as second-line treatment in all types of endogenous Cushings syndrome (CS). However, a direct comparison of these three drugs is missing. This study aimed to compare these drugs in the short-term therapy of CS.Design: Retrospective multicenter study involving 16 centers worldwide.Methods: Patients with CS treated with metyrapone...